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KMID : 0043320070300101236
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Archives of Pharmacal Research
2007 Volume.30 No. 10 p.1236 ~ p.1239
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Inhibition of Inducible Prostaglandin E2 Production and Cyclooxygenase-2 Expression by Curdione from Curcuma zedoaria
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Oh O-Jin
Min Hye-Young
Lee Sang-Kook
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Abstract
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Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentrationdependent manner (IC50 = 1.1 μM). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione
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